Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transcription Factor 4 (TCF4)
- Target
- TCF4
- Molecular classification
- Transcription factor, Basic helix-loop-helix transcription factor, E-protein
01
Overview
Transcription Factor 4 (TCF4), also known as Immunoglobulin Transcription Factor 2 (ITF-2), is a protein encoded by the TCF4 gene. It is a member of the class I basic helix–loop–helix (bHLH) family of transcription factors, commonly referred to as E-proteins. TCF4 regulates gene expression by binding to E-box sequences and is critical for neurodevelopment, cell differentiation, and apoptosis. Mutations in TCF4 are associated with Pitt-Hopkins Syndrome.
- Other names
- Immunoglobulin Transcription Factor 2ITF-2
02
Mechanism of action
TCF4 acts as a transcription factor that binds to E-box sequences (5'-CANNTG-3') in DNA, regulating gene expression by forming homo- or heterodimers with other bHLH proteins.
03
Biological functions
Transcription regulationNeurodevelopmentCell differentiationApoptosisRegulation of epithelial-mesenchymal transitionImmune cell development
04
Disease associations
Pitt-Hopkins SyndromeDistal 18q deletion syndromeNeurodevelopmental disorders
05
Safety considerations
Mutations in TCF4 can lead to severe neurodevelopmental disorders like Pitt-Hopkins Syndrome.Loss-of-function can lead to reduced Wnt signaling pathways impacting neural progenitor proliferation.
Beyond the preview
Go deeper on Transcription Factor 4 (TCF4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transcription Factor 4 (TCF4).