Transcription factor E2F4 (E2F4)

Transcription factor E2F4 (E2F4) is a member of the E2F family of transcription factors, which are critical regulators of cell cycle progression, DNA repair, apoptosis, and differentiation. E2F4 primarily acts as a transcriptional repressor via interactions with the pocket proteins p130 (RBL2) and p107 (RBL1), forming complexes that inhibit expression of proliferation-associated genes, but can also function as an activator in certain contexts[1][2][4]. It plays a role in enforcing cell cycle arrest, particularly in quiescent cells, and can bind to both promoters and distal genomic regions, influencing expression of protein-coding genes and non-coding RNAs; aberrant expression or mutation of E2F4 has been linked to oncogenic processes and human cancers[1][3][2][4].

Other names

E2F4E2F-4p107/p130-binding proteinE2F transcription factor 4p107/p130-bindingE2F family member 4

Transcriptional repression via recruitment of pocket proteins (p130, p107, pRB); Formation of repressor complexes; Modulation of cell cycle and cell fate genes; Regulation of enhancer elements at distal genomic sites