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Target intelligence / Profile preview
Transcription Factor E3 (TFE3)
- Target
- TFE3
- Molecular classification
- Transcription factor, bHLH-Zip transcription factor, MiTF/TFE family
01
Overview
Transcription factor E3 (TFE3) is a bHLH-Zip transcription factor belonging to the MiTF/TFE family. It regulates gene expression by binding to E-box and CLEAR-box sequences, playing a key role in lysosomal biogenesis, autophagy, immune response, and cellular metabolism. TFE3 activity is regulated by mTOR-dependent phosphorylation, controlling its nuclear translocation. Chromosomal translocations involving TFE3 are implicated in renal cell carcinomas and alveolar soft part sarcoma. It also interacts with Gα16, influencing cardiac hypertrophy. TFE3 is a therapeutic target in cancer.
02
Mechanism of action
mTOR-dependent regulation of phosphorylation/dephosphorylation and nuclear translocation
03
Biological functions
Lysosome biogenesis regulationAutophagy regulationImmune responseCellular adaptation to nutrient availabilityRegulation of pluripotencyRegulation of neuronal differentiation
04
Disease associations
CancerRenal cell carcinomaAlveolar soft part sarcomaCardiac hypertrophy
05
Safety considerations
Aberrant overexpression or altered function in cancerPotential off-target effects due to broad expression and pleiotropic functions
06
Biomarkers
TFE3 overexpression (IHC) in renal cell carcinoma and alveolar soft part sarcomaTFE3 fusion transcripts in renal cell carcinoma and alveolar soft part sarcoma
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