Transcription factor E4F1 (E4F1)

Transcription factor E4F1 (E4F1) is a multi-domain zinc finger protein with both transcription factor and E3 ubiquitin ligase activities. It regulates critical cellular processes such as the cell cycle, apoptosis, DNA damage response, and mitochondrial metabolism. E4F1 acts as a transcriptional repressor or activator based on context, notably modulating adenoviral gene expression in response to E1A and repressing or activating host cell genes associated with cell proliferation. It controls the activities of tumor suppressors p53 and pRB, participates in the DNA damage response by recruiting and regulating key repair factors, and influences cell differentiation and metabolic homeostasis. E4F1 is implicated in various pathological processes including cancer and neurodegenerative diseases due to its central role in cell cycle regulation and genome maintenance [1][2][3][5].

Other names

E4F1E4Fp120E4Fp50E4FPutative E3 ubiquitin-protein ligase E4F1RING-type E3 ubiquitin transferase E4F1

Modulation of transcriptional activity (repression/activation); Ubiquitination of chromatin-associated proteins (e.g., p53)