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Target intelligence / Profile preview
Transcription Factor EB (TFEB)
- Target
- TFEB
- Molecular classification
- Transcription factor, bHLH-Zip transcription factor
01
Overview
Transcription factor EB (TFEB) is a master regulator of cellular homeostasis and metabolism. As a member of the microphthalmia family of basic helix-loop-helix–leucine-zipper (bHLH-Zip) transcription factors (MiT family), TFEB functions as a master regulator of multiple cellular processes. It regulates lysosomal biogenesis, autophagy, mitochondrial biogenesis, and various metabolic processes. TFEB is activated by cellular stressors and has shown therapeutic potential in neurodegenerative diseases, while also playing complex roles in cancer and inflammatory responses.
- Other names
- MiTF/TFE familyMiT family
02
Mechanism of action
Modulation of TFEB activity to induce intracellular clearance of pathogenic factors or to restore lysosomal function.
03
Biological functions
Regulation of gene expressionLysosomal biogenesisAutophagy regulationMitochondrial biogenesisMetabolic regulationStress responseRegulation of lysosomal exocytosisImmune response
04
Disease associations
Neurodegenerative diseasesLysosomal storage disordersHuntington's diseaseParkinson's diseaseAlzheimer's diseaseRenal cell carcinomaPancreatic cancerBirt–Hogg–Dubé syndromeInflammationInfection
05
Safety considerations
Complex and context-dependent roles in cancer (oncogene vs. tumor suppressor)Potential for off-target effects due to involvement in multiple signaling pathways
06
Interacting drugs
Rapamycin
1 more in the full profile.
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