Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transcription factor GATA-5 (GATA5)
- Target
- GATA5
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Transcription factor GATA-5 (GATA5) is a zinc finger transcription factor encoded by the GATA5 gene on chromosome 20q13.33. It plays a critical role in cardiac development and morphogenesis, regulating genes required for heart formation and function, including atrial natriuretic factor and various muscle-specific proteins. GATA5 function is essential during embryogenesis, with loss-of-function mutations causing congenital heart disease such as Tetralogy of Fallot in humans and lethal cardiac defects in animal models. GATA5 interacts with other GATA family transcription factors to control downstream genetic programs critical for myocardial, endocardial, and smooth muscle cell differentiation.
- Other names
- Transcription factor GATA-5GATA5GATA-binding factor 5GATASCHTD5bB379O24.1GATA binding factor-5
02
Mechanism of action
Not applicable
03
Biological functions
Regulates cardiac development and morphogenesisControls expression of cardiac-specific genes (e.g., atrial natriuretic factor, brain natriuretic peptide, myosin heavy chain, troponins)Modulates smooth muscle and pulmonary tissue differentiation
04
Disease associations
Congenital heart disease (notably Tetralogy of Fallot and related cardiac malformations)Potential involvement in arrhythmias (through ectopic pacemaker activity when misregulated)Potential contributions to other congenital developmental disorders (based on animal models)
05
Safety considerations
Therapeutic targeting would present challenges due to roles in critical developmental gene regulationMutations or deregulation can lead to severe congenital heart defects
Beyond the preview
Go deeper on Transcription factor GATA-5 (GATA5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transcription factor GATA-5 (GATA5).