Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transcription factor Jun (c-Jun)
- Target
- c-Jun
- Molecular classification
- Transcription factor, bZIP transcription factor
01
Overview
Transcription factor Jun (c-Jun) is a key component of the AP-1 transcription factor complex, regulating gene expression related to cell proliferation, differentiation, apoptosis, tumorigenesis, and tissue morphogenesis. Its activity is modulated by phosphorylation via JNKs and it plays a role in various cancers and nerve regeneration.
- Other names
- JUNv-jun sarcoma virus oncogene homolog
02
Mechanism of action
Inhibition of JNK-mediated phosphorylation of c-Jun
03
Biological functions
Cell proliferationCell differentiationApoptosisTumorigenesisNerve regenerationTranscriptional regulationSignal integrationImmediate early response
04
Disease associations
CancerVulvar squamous cell carcinomaBreast cancerHematologic malignanciesMalignant melanomaSarcoma
05
Safety considerations
Potential for off-target effects due to broad role in cellular processesInhibition may disrupt normal cellular functions
06
Biomarkers
c-Jun overexpressionJUN amplification
Beyond the preview
Go deeper on Transcription factor Jun (c-Jun).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transcription factor Jun (c-Jun).