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Target intelligence / Profile preview
Transcription factor p65 subunit (RELA)
- Target
- RELA
- Molecular classification
- Transcription factor
01
Overview
Transcription factor p65, also known as RELA, is a critical subunit of the NF-κB transcription factor complex. It regulates genes involved in immune response, inflammation, cell proliferation/differentiation, and apoptosis. Dysregulation or constitutive activation has been linked to cancer development and autoinflammatory diseases.
- Other names
- p65RELANFKB3
02
Mechanism of action
Inhibition of NF-κB signaling pathway by blocking RELA/p65 activation, nuclear translocation, or DNA binding.
03
Biological functions
Immune responseInflammationCell proliferation/differentiationApoptosisGene expression regulation
04
Disease associations
Autoinflammatory Disease Familial Behcet-Like Syndrome Type 3Rela Fusion–Positive EpendymomaCancer
05
Safety considerations
Potential for immunosuppressionOff-target effects due to broad role in gene regulation
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