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Target intelligence / Profile preview
Transcription factor RelB (RelB)
- Target
- RelB
- Molecular classification
- Transcription factor, NF-kappa-B family member
01
Overview
Transcription factor RelB is a member of the NF-κB family of transcription factors, playing a central role in regulating immune and inflammatory responses. It primarily functions within the non-canonical NF-κB signaling pathway, forming heterodimers with p52 to regulate gene expression involved in lymphoid organogenesis and immune cell trafficking. Deficiencies or mutations in RELB are associated with immunodeficiency disorders and multiorgan inflammation. It is expressed predominantly in interdigitating dendritic cells within lymphoid tissues.
- Other names
- RELBI-Rel
02
Mechanism of action
Modulation of NF-κB signaling pathway
03
Biological functions
Transcriptional regulatorImmune response regulationInflammatory response modulationLymphoid organ developmentRegulation of gene expression
04
Disease associations
Immunodeficiency disordersGeneralized immune deficiency diseasesMultiorgan inflammationSevere systemic inflammation
05
Safety considerations
Potential for broad immune dysregulationRisk of multiorgan inflammation when deficient or dysfunctional
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