Transcription factor RFX4 (RFX4)

Transcription factor RFX4 is a protein encoded by the RFX4 gene, belonging to the regulatory factor X gene family and characterized by a winged-helix DNA-binding domain[1][3][2][6]. RFX4 is mainly involved in the transcriptional regulation of genes important for early brain and neural tube development and may influence neural tube ciliogenesis and Shh signaling. Several alternative splice isoforms exist, with tissue-specific expression in the central nervous system and testis. RFX4 interacts with other family members (RFX2, RFX3) and can act as a repressor or activator at target promoters, depending on cellular context. Dysfunction or mutation of RFX4 is implicated in rare developmental disorders such as Dandy-Walker syndrome and certain brain tumors like melanotic medulloblastoma[1][3][4][6].

Other names

Regulatory factor X4Testis development protein NYD-SP10RFX4NYD-SP10Winged-helix transcription factor RFX4Regulatory factor X, 4 (influences HLA class II expression)

Not applicable (no drugs currently known to target RFX4 directly)