Transcription initiation factor TFIID subunit 10 (TAF10)

Transcription initiation factor TFIID subunit 10 (TAF10) is a small subunit of the TFIID complex, a multi-protein assembly required for the initiation of transcription by RNA polymerase II in eukaryotes[1][5]. TFIID consists of the TATA-box binding protein (TBP) and a set of TBP-associated factors (TAFs), of which TAF10 is one. TAF10 functions as a structural and regulatory component, participating in promoter recognition, chromatin modification, and assembly of the transcription pre-initiation complex. It is also involved in gene-selective transcription regulation, progression of the cell cycle, and acts as a coactivator for nuclear hormone receptors such as the estrogen receptor[1][5]. TAF10 is essential for early embryonic development and inner cell mass survival; its genetic disruption leads to instability of the TFIID complex and arrest of transcription, highlighting its crucial role in gene expression regulation[3][5]. TAF10 also contributes to the assembly of multiprotein chromatin regulatory complexes related to TFIID, including PCAF, STAGA, and TFTC, which have histone acetyltransferase activity critical for chromatin remodeling and activation of transcription[3]. Note: TAF10 is not a classical drug target like a receptor or enzyme but is essential in fundamental transcriptional regulation. No direct therapeutic drugs or biomarkers are documented for TAF10 in the current literature[5]. Mutations in TAF10 are linked to severe developmental disorders, notably certain forms of developmental and epileptic encephalopathies[5].

Other names

TATA-box binding protein associated factor 10TAFII30TAF subunit 10TAF10 protein