Transcription initiation factor TFIID subunit 13 (TAF13)

ENSG00000216324 refers to a pseudogene of TAF13, not the canonical active gene. The canonical, protein-coding TAF13 gene (HGNC:11546, ENSG00000197780) encodes a small, evolutionarily conserved subunit of the TFIID complex, critical for RNA polymerase II transcription initiation[1][2][6]. TAF13 interacts with the TATA-binding protein (TBP) and other TFIID subunits and participates in promoter recognition and assembly of the transcription preinitiation complex[1][6]. Mutations or dysfunction of the protein-coding TAF13 are linked to disorders such as intellectual developmental disorder and microcephaly[2]. As a pseudogene, ENSG00000216324 is not considered a therapeutic target and likely does not encode a functional protein product[1][2]. Key points regarding this query: - ENSG00000216324 is a pseudogene, not the canonical protein-coding gene; the functional gene is ENSG00000197780[2][5]. - TAF13 is a transcription factor subunit, not a drug target or receptor, so designations like "interacting drugs," "mechanism of action," or "biomarkers" are not applicable. - Possible confusion/incorrectness due to use of the pseudogene rather than the functional gene[1][2]. - The main molecular functions relate to transcription initiation and complex assembly rather than classical therapeutic targeting[1][6].

Other names

TATA-box binding protein associated factor 13TAF2K