Transcription initiation factor TFIID subunit 5 (TAF5)

Transcription initiation factor TFIID subunit 5 (TAF5) is a core component of the TFIID complex, which is essential for the initiation of transcription by RNA polymerase II[1][6]. TFIID includes the TATA-box-binding protein (TBP) and multiple TBP-associated factors (TAFs), with TAF5 acting as a structural and functional subunit involved in the formation of nucleosome-like structures within TFIID[1][2]. TAF5 mediates protein–protein interactions within the TFIID complex, contributes to promoter recognition, and is involved in the assembly of the pre-initiation complex necessary for accurate transcription initiation[1][2][6]. The TFIID complex, with TAF5, functions broadly in gene expression and is implicated in the cellular response to various activators and repressors[2]. While genetic variations in TAF5 have been associated with certain cancers such as prostate adenocarcinoma and medulloblastoma, TAF5 itself is not a typical drug target and there are no known therapeutic agents that selectively modulate its activity[1].

Other names

TAF2DTAF(II)100TAFII-100TAFII100Transcription initiation factor TFIID 100 kDa subunitTAF5 RNA polymerase IITATA box binding protein (TBP)-associated factor 100kDaTATA box binding protein (TBP)-associated factor 2DTATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD