Transcription initiation factor TFIID subunit 9B (TAF9B)

Transcription initiation factor TFIID subunit 9B (TAF9B) is a subunit of the multiprotein TFIID complex, which is essential for the initiation of RNA polymerase II-mediated transcription[1][2][3][4][6]. TAF9B shares some functions with its paralog TAF9, but also has unique roles in regulating distinct gene sets[2][6]. TAF9B is necessary for cell viability and is involved in both transcriptional activation and repression. It may play a role in the regulation of apoptosis and participates in complex assembly and control of gene expression in eukaryotic cells[2][4]. Notably, TAF9B itself is not a conventional therapeutic target such as a receptor, enzyme, or transporter; it acts primarily as a core transcription regulatory factor. The gene listed in your query, ENSG00000253176, refers to a pseudogene (LOC100130612)[4], and not the active coding gene (ENSG00000187325). Thus, ENSG00000253176 likely does not code for a functional protein, and should not be considered a protein-coding drug target.

Other names

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDaTranscription initiation factor TFIID subunit 9BTranscription-associated factor TAFII31LNeuronal cell death-related protein 7Transcription initiation factor TFIID subunit 9-likeTranscription initiation factor IID, 31kD subunitTBP-associated factor 9LTAF9L (former name)LOC100130612 (alternative locus)

Not applicable (no drug interactions reported)