Transcription termination factor 2 (TTF2)

Transcription termination factor 2 (TTF2) is a member of the SWI2/SNF2 family and encodes a dsDNA-dependent ATPase that functions as a transcription termination factor by coupling ATP hydrolysis with the active removal of RNA polymerase II from the DNA template[1][2][6]. TTF2 interacts with proteins such as cell division cycle 5-like and is involved in pre-mRNA splicing, chromatin remodeling, and mitotic transcription repression[1][2][3][4][6]. TTF2 is essential for proper control of gene expression during development and cell cycle progression, and its genetic locus is on human chromosome 1[1][4]. No direct associations with therapeutically targeted diseases or drugs have been documented in the current sources, and no established biomarkers or safety concerns are reported as of now.

Other names

F2HuF2ZGRF6transcription termination factor, RNA polymerase IIlodestar homologtranscription release factor 2zinc finger GRF-type containing 6