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Target intelligence / Profile preview
Transcriptional adaptor 1 (TADA1)
- Target
- TADA1
- Molecular classification
- Transcription coactivator, Histone acetyltransferase complex component, Nuclear protein
01
Overview
Transcriptional adaptor 1 (TADA1) is a 335-amino acid nuclear protein, widely expressed across tissues, and is a member of the STAGA transcription coactivator–HAT complex. Its primary function is in the regulation of transcription, likely by facilitating histone acetylation and enhancing gene activation by RNA polymerase II. While TADA1 is frequently studied for its role in basic transcriptional mechanisms and is found as a fusion gene in some cancers—including lung adenocarcinoma—it is not currently considered a therapeutic target and no drugs directly interact with it. Its main significance is scientific, relating to chromatin biology and transcription regulation.
- Other names
- ADA1HFI1hADA1STAF42TADA1LSPT3-associated factor 42Transcriptional adapter 1-like proteintranscriptional adapter 1 (HFI1 homolog, yeast)
02
Biological functions
Transcriptional regulation by RNA polymerase IIHistone H3 acetylation (chromatin modification)
03
Disease associations
Fusion of TADA1 with other genes (e.g., CADM3) observed in cancer, including lung adenocarcinomaPotential involvement in broader disease contexts due to location on chromosome 1, which is associated with several diseases, but no direct pathogenic mutations linked
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