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Transcriptional adaptor 2B (TADA2B)

Target: TADA2B
Molecular classification: Transcriptional coactivator, Chromatin-binding protein, Histone acetyltransferase complex component, SANT/Myb domain-containing protein

Overview

Transcriptional adaptor 2B (TADA2B) is a protein-coding gene encoding a transcriptional coactivator that functions as a component of histone acetyltransferase (HAT) complexes. It enhances transcription by promoting HAT activity and facilitating interactions between activating transcription factors and the basal transcriptional machinery. TADA2B is involved in chromatin remodeling and regulation of gene expression, and can coactivate PAX5-dependent transcription, notably with SMARCA4 or GCN5L2 partners. Associated disease from current data includes spinocerebellar ataxia 7, likely due to general chromatin dysregulation. Its essential physiological role is in the epigenetic regulation of gene expression, but it is not currently considered a therapeutic drug target.

Other names: ADA2BADA2-betaADA2-like protein betaADA2(beta)MGC21874Transcriptional adapter 2-beta

Biological functions

Transcriptional regulationChromatin remodelingCoordination of histone acetyltransferase (HAT) activityLinking activation factors to basal transcriptional machineryCoactivation of PAX5-dependent transcription with SMARCA4 or GCN5L2

Disease associations

Spinocerebellar ataxia 7Other (as a general chromatin regulator, dysregulation could be linked to various diseases, but limited evidence for direct involvement)

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