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Transcriptional coactivator with PDZ-binding motif (TAZ)
- Target
- TAZ
- Molecular classification
- Transcription factor, Transcriptional coregulator
01
Overview
Transcriptional coactivator with PDZ-binding motif (TAZ), encoded by the *WWTR1* gene, is a transcriptional coregulator protein. TAZ plays a central role in regulating gene expression associated with development, cell growth, survival, and inhibition of apoptosis. It acts as a transcriptional coactivator by interacting directly with various transcription factors. TAZ activity is tightly regulated by phosphorylation and the Hippo signaling pathway. Aberrant regulation or overactivity of TAZ has been linked to oncogenesis in several cancers. Deficiency causes developmental defects such as impaired spermatogenesis.
- Other names
- WWTR1WW domain-containing transcription regulator protein 1
02
Mechanism of action
Transcriptional coactivation through interaction with transcription factors
03
Biological functions
Transcriptional coactivationRegulation of stem cell proliferationRegulation of stem cell differentiationOrgan developmentCell growthCell survivalInhibition of apoptosisMyogenic differentiationOsteoblast/adipocyte fate determination
04
Disease associations
CancerDevelopmental defectsImpaired spermatogenesisEndothelial dysfunctionCardiovascular diseaseAtherosclerosis
05
Safety considerations
Oncogenic driver in cancer when Hippo signaling is dysregulated
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