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Transcriptional Enhanced Associate Domain (TEAD)
- Target
- TEAD
- Molecular classification
- Transcription factor
01
Overview
Transcriptional enhanced associate domain (TEAD) proteins are a family of transcription factors that serve as the primary downstream effectors of the Hippo signaling pathway, which is crucial for regulating cell proliferation, tissue homeostasis, stem cell function, and organ size. TEADs require coactivators—most notably Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ)—to activate gene transcription. High expression or dysregulation of TEADs is linked to various cancers and disrupting the interaction between YAP/TAZ and TEAD is an active area for anti-cancer drug development.
- Other names
- TEF-1NTEFTEF-4ETFTEF-5ETFR-1TEF-3ETFR-2FR-19
02
Mechanism of action
Inhibition of YAP/TAZ-TEAD interaction
03
Biological functions
Cell proliferationTissue homeostasisStem cell maintenanceCell growthSurvivalDifferentiationTissue regenerationStemness
04
Disease associations
Cancer
05
Biomarkers
High TEAD expression (prognostic)
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