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Transcriptional Enhanced Associate Domain Protein (TEAD)
- Target
- TEAD
- Molecular classification
- Transcription factor
01
Overview
Transcriptional enhanced associate domain proteins (TEADs) are a family of transcription factors that regulate gene expression related to cell proliferation, growth, and stem cell function. They are downstream effectors of the Hippo signaling pathway. There are four human TEAD genes: TEAD1, TEAD2, TEAD3, and TEAD4. TEADs bind to MCAT elements and require coactivators like YAP/TAZ to activate transcription. The YAP/TAZ–TEAD axis is linked to many cancers, making it a therapeutic target.
- Other names
- TEA domain family member 1TEA domain family member 2TEA domain family member 3TEA domain family member 4Transcription enhancer factor (TEF) proteinsTEF-1/NTEF (TEAD1)TEF-4/ETF (TEAD2)
02
Mechanism of action
Disrupting YAP/TAZ–TEAD interactions
03
Biological functions
Cell proliferationCell growth regulationStemnessTissue regenerationTranscription regulation
04
Disease associations
Cancer
05
Biomarkers
TEAD expression levels in tumors
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