Transcriptional enhanced associate domain protein 4 mRNA (TEAD4 mRNA)

Transcriptional enhanced associate domain protein 4 (TEAD4) mRNA is the transcript encoding a key transcription factor within the Hippo signaling pathway. The TEAD4 protein acts as a primary nuclear partner for the transcriptional co-activators YAP and TAZ, facilitating the expression of genes that promote cell survival, proliferation, and stemness (PMID: 31434659). In various malignancies, TEAD4 is frequently overexpressed or hyperactivated, contributing to tumor progression, metastasis, and resistance to therapy (PMID: 30217974). Targeting TEAD4 at the mRNA level using antisense oligonucleotides or RNA interference offers a strategy to deplete the protein product, which is traditionally considered difficult to target with small molecules due to its lack of conventional binding pockets. This approach aims to disrupt the YAP/TAZ-TEAD transcriptional output, thereby inhibiting oncogenic signaling in Hippo-deficient or YAP/TAZ-driven cancers. By reducing the levels of TEAD4 mRNA, researchers hope to suppress the epithelial-mesenchymal transition and increase the sensitivity of cancer cells to existing treatments (NCBI Gene ID: 7004).

Other names

TEA domain family member 4 mRNATranscription factor 13 mRNATCF13 mRNATEF-3 mRNARTEF-1 mRNAhRTEF-1 mRNA

RNA interference (RNAi) or RNase H-mediated degradation of the mRNA transcript to prevent translation into the TEAD4 protein, thereby inhibiting the formation of the YAP/TAZ-TEAD transcriptional complex.