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Transcriptional Enhanced Associate Domain protein family (TEAD)
- Target
- TEAD
- Molecular classification
- Transcription factor
01
Overview
The TEAD (Transcriptional Enhanced Associate Domain) protein family comprises a group of highly conserved transcription factors essential for development, organogenesis, and disease processes such as cancer. In mammals, there are four main members: TEAD1, TEAD2, TEAD3, and TEAD4. They function as transcription factors by binding to DNA and interacting with coactivators like YAP and TAZ. Aberrant activation of the Hippo-YAP/TAZ–TEAD axis promotes tumorigenesis, making it a potential anti-cancer target.
- Other names
- TEF-1TCF-13
02
Mechanism of action
Disruption of YAP/TAZ–TEAD interaction
03
Biological functions
Transcriptional regulationDevelopmentOrganogenesisCell proliferationCell differentiationApoptosis
04
Disease associations
Cancer initiationCancer progressionTumorigenesisMetastasis
05
Safety considerations
Aberrant activation promotes tumorigenesis
06
Biomarkers
TEAD3 expression in head-and-neck squamous cell carcinomaTEAD4 expression in head-and-neck squamous cell carcinoma
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