Transcriptional regulating factor 1 (TRERF1)

Transcriptional regulating factor 1 (TRERF1) is a zinc-finger transcription factor that functions as a coactivator by physically interacting with key nuclear receptors such as steroidogenic factor-1 (SF-1) and coactivators like CBP/p300[1][2][3]. It upregulates the transcription of genes essential for steroid biosynthesis—including CYP11A1, P450scc, P450c17, and aromatase—by binding DNA and enhancing promoter activity, leading to increased production of steroid hormones (e.g., glucocorticoids, C₁₉ steroids, estrogens)[1][3]. TRERF1 also exerts anti-proliferative effects in various cell types by upregulating cyclin-dependent kinase inhibitors (notably p21 and p27) and synergizes with steroid hormone receptors, such as the progesterone receptor, to modulate cell cycle arrest and differentiation[1]. Mutations or dysregulation of TRERF1 have been observed in diseases such as breast cancer and endometriosis, where it may influence steroid responsiveness and cell proliferation[1][3][4]. No direct drug interactions or mechanisms of drug action targeting TRERF1 are currently established, and its use as a clinical biomarker is investigational rather than routine.

Other names

TReP-132BCAR2RAPATREP132HSA277276dJ139D8.5Breast cancer anti-estrogen resistance 2Transcriptional-regulating protein 132Zinc finger protein rapaZinc finger transcription factor TReP-132