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Target intelligence / Profile preview
Transducin beta-like protein 1 (TBL1)
- Target
- TBL1
- Molecular classification
- WD40 repeat-containing proteins, Adaptor protein, Scaffold protein
01
Overview
Transducin beta-like protein 1 (TBL1) is an adaptor and scaffold protein that plays a crucial role in transcriptional regulation, particularly within the Wnt/β-catenin signaling pathway. It acts as a corepressor complex component and interacts with the SCF E3 ubiquitin ligase complex. TBL1 dysregulation is implicated in various cancers, especially DLBCL, making it a potential therapeutic target. Approaches include small molecule inhibitors like tegavivint and PROTAC-based degraders.
- Other names
- TBL1X
02
Mechanism of action
Disrupts TBL1-β-catenin interaction; PROTAC-mediated degradation of TBL1
03
Biological functions
Transcriptional repressionWnt/β-catenin signaling regulationProtein-protein interactionUbiquitin ligase complex component
04
Disease associations
CancerDiffuse large B-cell lymphoma (DLBCL)Ocular albinism with late-onset sensorineural deafness (potential)
05
Safety considerations
Potential off-target effects due to involvement in multiple regulatory networks
06
Interacting drugs
Tegavivint (BC2059)
07
Biomarkers
TBL1 expression levels in DLBCL
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