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Target intelligence / Profile preview
Transepidermal Water Loss (TEWL)
- Target
- TEWL
- Molecular classification
- Physiological process, Biomarker
01
Overview
Transepidermal water loss (TEWL) refers to the passive evaporation of water from inside the body through the epidermis into the external environment. It is a natural process that helps regulate hydration levels and serves as an indicator of skin barrier integrity. Low TEWL suggests healthy skin, while elevated TEWL indicates compromised barrier function. Several internal and external factors influence TEWL, including skin barrier health, environmental conditions, age, body site, and skin disorders. Management strategies include using moisturizers and avoiding harsh cleansers.
02
Mechanism of action
Humectants attract moisture into the upper layers of the skin; occlusive agents form a protective film preventing evaporation.
03
Biological functions
Regulation of cutaneous hydrationMaintenance of skin barrier integrity
04
Disease associations
EczemaAtopic dermatitisSkin damageDry skinHyperpigmentation
05
Safety considerations
Excessive TEWL leading to dehydrationCompromised skin barrier functionPotential irritation from harsh cleansers/ingredients
06
Interacting drugs
Humectants (e.g., hyaluronic acid)
1 more in the full profile.
07
Biomarkers
TEWL measurement
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