Transfer RNA leucine pseudogene

The "transfer RNA leucine pseudogene" (ENSG00000271900) is a **pseudogene**, meaning it is a genomic DNA sequence similar to that of a functional tRNA-Leu gene but is non-functional due to mutations in its sequence, structure, or regulatory regions[3]. Pseudogenes arise through gene duplication or retrotransposition, but accumulate disabling mutations such as frameshifts, premature stop codons, or loss of regulatory elements, preventing normal transcription or function as a tRNA. While functional transfer RNA-Leu molecules are essential for protein translation by delivering leucine to the ribosome, pseudogenes do not participate in canonical amino acid transfer or translation. Some pseudogenes can exert regulatory effects at the RNA level, such as acting as decoys for RNA-binding proteins or small RNAs, but there is currently no evidence that ENSG00000271900 plays a role as a protein target, disease gene, or therapeutic target[3].

Other names

tRNA-Leu pseudogenetRNA^Leu pseudogeneLeucine tRNA pseudogene