Transfer RNA with GU anticodon

Transfer RNA (tRNA) molecules with GU anticodons enable recognition of multiple codons through "wobble" base pairing at the third codon position. According to the wobble hypothesis, when the first nucleotide of a tRNA anticodon is G or U, it can pair with more than one mRNA base during translation (e.g., G can pair with C or U, and U can pair with A or G)[4]. This property reduces the number of distinct tRNAs required to decode all codons and allows for efficient translation but can increase tolerance for certain types of codon-anticodon mismatches, which may result in non-standard amino acid incorporation[1][3]. tRNAs are not generally considered therapeutic targets or specific receptors, enzymes, or transporters. Instead, they are essential components of the translation machinery[2][4]. While synthetic or engineered tRNAs have been studied for translational suppression or recoding purposes, natural tRNAs with GU anticodons are not themselves classified as drug targets or disease biomarkers[1][3][5]. **Note:** This query describes a structural feature of a class of tRNAs, not a specific gene, protein, or canonical drug target. The "target" as requested is thus ambiguous, lacks a standardized singular target entity, and does not match the conventions used for classical therapeutic molecular targets.

Other names

tRNA with GU anticodonGU-anticodon tRNAGU wobble tRNA