Target intelligence / Profile preview

Transferrin (TF)

Target: TF
Molecular classification: Glycoprotein, Iron-binding protein, Transport protein

Overview

Transferrin is a glycoprotein primarily responsible for binding and transporting iron (Fe³⁺) in the blood plasma. It plays a crucial role in iron homeostasis, transporting iron from absorption sites or storage centers to tissues throughout the body. Serum transferrin levels are clinically measured for diagnosing iron deficiency anemia or hemochromatosis. Carbohydrate-deficient forms can be used diagnostically for certain liver diseases.

Mechanism of action

N/A

Biological functions

Iron transportIron homeostasisAntimicrobial activity (iron sequestration)Iron buffering

Disease associations

Iron deficiency anemiaHemochromatosisAlcoholic liver disease

Biomarkers

Serum transferrin levels (anemia, iron overload)Carbohydrate-deficient transferrin (alcoholic liver disease)

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