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Target intelligence / Profile preview
Transferrin Receptor (TfR)
- Target
- TfR
- Molecular classification
- Receptor, Transmembrane protein, Glycoprotein
01
Overview
The transferrin receptor (TfR) is a membrane glycoprotein essential for cellular iron uptake. It mediates the import of iron into cells by binding to transferrin, an iron-carrying plasma glycoprotein, and internalizing the transferrin-iron complex through receptor-mediated endocytosis. It is a target for cancer therapy due to its overexpression on cancer cells.
- Other names
- CD71TFR1TFR2HFE3Transferrin receptor 1Transferrin receptor 2
02
Mechanism of action
Targeted delivery of drugs, nanoparticles, immunotoxins, and gene therapy vectors. Direct inhibition can induce cytotoxicity.
03
Biological functions
Iron uptakeReceptor-mediated endocytosisCell growth and proliferationErythropoiesis
04
Disease associations
AnemiaCancerErythropoietic disordersIron overload disorders
05
Safety considerations
Potential for off-target effects due to ubiquitous expressionLimited tumor specificity may lead to toxicity in normal tissuesDevelopment of resistance mechanisms
06
Biomarkers
Soluble transferrin receptor (sTfR) in serum
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