Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transforming acidic coiled-coil-containing protein 1 (TACC1)
- Target
- TACC1
- Molecular classification
- Other (member of the TACC protein family; not classified as a receptor, enzyme, transporter, or transcription factor)
01
Overview
Transforming acidic coiled-coil-containing protein 1 (TACC1) is a member of the TACC protein family, characterized by a large carboxy-terminal coiled-coil domain. TACC1 is implicated in regulating transcription, translation, and centrosome dynamics by interacting with a variety of protein complexes. It functions downstream of growth factor and oncogenic signaling, particularly Ras and PI3K/AKT/mTOR pathways, promoting cell survival and proliferation. TACC1 is frequently overexpressed or aberrantly spliced in several cancers and can enhance tumor formation and decrease apoptosis. It interacts with proteins involved in cell division and the mitotic spindle, such as Aurora kinases and CKAP5, but has minimal direct association with microtubule stabilization. While TACC1 is considered a potential biomarker and cancer target, no direct therapeutics targeting TACC1 are currently approved.
- Other names
- KIAA1103Gastric cancer antigen Ga55Taxin-1Ga55
02
Biological functions
Regulation of transcriptionRegulation of translationCentrosome dynamicsCell proliferationCell survivalPromotion of autophagy
03
Disease associations
Cancer (evidence in breast cancer, gastric cancer, rhabdomyosarcoma, leukemia, ovarian cancer, and head and neck squamous cell carcinoma)
04
Safety considerations
Oncogenic activity when overexpressedPotential for chromosomal instability if upregulated or downregulatedSplice variant-dependent functional effects, complicating targeting efforts
05
Biomarkers
Overexpression or alternative splicing variants in cancer may be biomarker candidates
Beyond the preview
Go deeper on Transforming acidic coiled-coil-containing protein 1 (TACC1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transforming acidic coiled-coil-containing protein 1 (TACC1).