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Transforming acidic coiled-coil containing protein 1 pseudogene 1 (TACC1P1)

Target: TACC1P1
Molecular classification: Other (Pseudogene; not receptor, enzyme, transporter, transcription factor, ion channel, etc.)

Overview

TACC1P1 is a human pseudogene—a genomic locus highly homologous to the transforming acidic coiled-coil containing protein 1 gene (TACC1), but with mutations or truncations that render it non-protein-coding[1]. Pseudogenes are generally considered non-functional genomic sequences, though recent research suggests that some pseudogenes may participate in regulation of gene expression by acting as competitive endogenous RNAs, serving as microRNA decoys or influencing the stability of their parent gene transcripts[5]. There is currently no evidence that TACC1P1 has any such functional activity, drug interactions, or direct roles in disease. TACC1P1 is distinctly not a protein, receptor, enzyme, or molecular target as conventionally defined—it is a pseudogene. Querying it as a target is likely incorrect unless studying pseudogene-derived regulatory RNA.

Other names: TACC1 pseudogene 1Transforming acidic coiled-coil containing protein 1 pseudogene 1

Biological functions

No known direct biological function for TACC1P1.General pseudogene literature suggests possible non-coding RNA regulatory roles, such as acting as a microRNA decoy (competing for miRNA binding to regulate expression of the parent gene, as seen with other pseudogenes like PTENP1, but not specifically shown for TACC1P1).

Disease associations

No direct associations for TACC1P1 in disease.Parent gene TACC1 is associated with disease roles including Cancer (amplifications in breast cancer region), Glioblastoma, and Gliosarcoma.If TACC1P1 were shown to act as a regulatory pseudogene (no data for this), theoretical roles could include modulation in cancer via regulation of TACC1 expression.

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