Transforming acidic coiled-coil containing protein 2 (TACC2)

Transforming acidic coiled-coil containing protein 2 (TACC2) is a member of the TACC family of proteins, characterized by a conserved C-terminal TACC domain and primarily associated with centrosome and microtubule interactions throughout the cell cycle[3][4]. TACC2 is implicated in the regulation of centrosome-mediated processes including nuclear migration and microtubule organization[3][4]. It is expressed at low levels in many postmitotic tissues such as brain, kidney, lung, thymus, and ovary, with various isoforms arising from complex splicing and promoter usage[2][5]. Although earlier studies suggested roles as both tumor suppressor and oncogenic factor, TACC2 is currently recognized more as a potential cancer biomarker; its overexpression is associated with increased cell proliferation and poor prognosis in breast cancer[1][3][5]. Functional studies in mice indicate TACC2 is not required for normal development or tumor suppression, suggesting redundancy in its biological functions[2]. TACC2 is not currently recognized as a direct therapeutic target, nor are there known small molecules or drugs that specifically modulate its activity.

Other names

AZU-1ECTACCAnti-Zuai-1transforming acidic coiled-coil-containing protein 2anti zuai-1