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Target intelligence / Profile preview
Transforming acidic coiled-coil containing protein 3 (TACC3)
- Target
- TACC3
- Molecular classification
- Coiled-coil protein, Centrosomal protein, Mitotic spindle-associated protein
01
Overview
Transforming acidic coiled-coil containing protein 3 (TACC3) is a centrosomal and mitotic spindle-associated protein crucial for cell division. It regulates microtubule dynamics and spindle assembly, preventing aneuploidy. Overexpressed in various cancers, TACC3 promotes proliferation, migration, invasion, and stemness. It is a therapeutic target, especially in tumors with centrosome amplification or FGFR-TACC fusions. High expression is found in hematopoietic tissues. Therapeutically targeting TACC3 or its interactors could selectively impair tumor cells reliant on its function for survival.
- Other names
- ERIC1ERIC-1maskinTacc4
02
Mechanism of action
TACC3 inhibitors (in development)
03
Biological functions
Mitotic spindle assemblyMicrotubule organizationCell divisionKinetochore capture regulation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad expression in hematopoietic tissuesCentrosome amplification present in some cancers can modulate response
06
Biomarkers
TACC3 overexpression
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