Transforming growth factor-β-activated kinase 1–TAK1-binding protein 1 complex (TAK1-TAB1 complex)

The TAK1-TAB1 complex is a central mediator of inflammatory and stress signaling in mammalian cells. TAK1 (MAP3K7) is a serine/threonine kinase activated by cytokines and receptor ligands, leading to activation of NF-κB and MAPK pathways. TAB1 acts as an adapter that binds to TAK1, enhancing its kinase activity and facilitating downstream signaling. The complex is regulated by post-translational modifications, including phosphorylation and ubiquitination, and is essential for mediating cellular responses to proinflammatory stimuli, regulating cell death pathways, and modulating immune and stress responses in health and disease.

Other names

TAK1–TAB1 complexMAP3K7–TAB1 complexTGF-β-activated kinase 1–TAB1 complex

Kinase inhibition (drugs inhibit TAK1's kinase activity, blocking NF-κB and MAPKs activation); Disruption of protein–protein interaction (e.g., agents interfering with TAK1–TAB1 binding)