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Target intelligence / Profile preview
Transforming Growth Factor β Receptor 2 (TGFBR2)
- Target
- TGFBR2
- Molecular classification
- Receptor, Transmembrane serine/threonine protein kinase
01
Overview
Transforming growth factor β receptor 2 (TGFBR2) is a transmembrane serine/threonine protein kinase and a key component of the TGF-β signaling pathway. It plays a critical role in regulating cell proliferation, differentiation, motility, apoptosis, and tumor suppression.
02
Mechanism of action
TGFBR2 phosphorylates and activates type I receptors, triggering downstream phosphorylation of SMAD proteins that regulate gene transcription.
03
Biological functions
Signal transductionCell proliferationDifferentiationApoptosisMotilityWound healingImmune system functionExtracellular matrix formationTumor suppressionCell cycle control
04
Disease associations
Marfan syndrome-related disordersLoeys-Deitz syndromeOsler–Weber–Rendu syndromeCancer
05
Safety considerations
Mutations or loss-of-function can lead to uncontrolled proliferation associated with various cancers.
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