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Target intelligence / Profile preview
Transforming Growth Factor β Receptor Type II (TGFBR2)
- Target
- TGFBR2
- Molecular classification
- Receptor, Protein Kinase, Serine/Threonine Kinase, Tyrosine Kinase
01
Overview
Transforming growth factor β receptor type II (TGFBR2) is a transmembrane serine/threonine protein kinase and a key component of the TGF-β signaling pathway. It functions as a tumor suppressor gene and plays critical roles in regulating cell proliferation, differentiation, apoptosis, and extracellular matrix production. Upon ligand binding, TGFBR2 forms heteromeric complexes with TGF-beta receptor type I (TGFBR1), initiating downstream signaling cascades.
02
Mechanism of action
TGFBR2 phosphorylates TGFBR1, initiating downstream signaling cascades through SMAD proteins and non-Smad pathways (MAPK/ERK, JNK/p38 MAP kinases, PI3K/Akt, Src tyrosine kinases, and Rho GTPases).
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosisExtracellular matrix productionImmune response modulationTissue homeostasisDevelopment
04
Disease associations
Marfan syndromeLoeys-Dietz syndromeOsler–Weber–Rendu syndromeCancer/Tumors
05
Safety considerations
Potential for broad effects on cell growth and differentiation due to its role in multiple signaling pathways.Mutations can lead to various diseases, highlighting the importance of careful targeting.
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