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Transforming Growth Factor Alpha (TGF-α)

Target: TGF-α
Molecular classification: Growth Factor, Ligand

Overview

Transforming growth factor alpha (TGF-α) is a protein that belongs to the epidermal growth factor (EGF) family and functions as a mitogenic polypeptide, meaning it stimulates cell division. TGF-α acts as a ligand for the epidermal growth factor receptor (EGFR), triggering signaling pathways that regulate cell proliferation, differentiation, and development. Abnormal expression or regulation of TGF-α has been implicated in several diseases, including cancer and developmental disorders.

Other names: Sarcoma growth factorTGF-type IETGF

Mechanism of action

TGF-α binds to EGFR (ErbB1), activating its intrinsic tyrosine kinase activity, initiating downstream signaling cascades involved in cell proliferation, differentiation, development, and survival.

Biological functions

Cell proliferationCell differentiationDevelopmentSurvivalMitogenic activityInhibition of gastric acid secretion

Disease associations

CancerDevelopmental Disorders

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