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Target intelligence / Profile preview
Transforming Growth Factor Beta 3 (TGF-beta 3)
- Target
- TGF-beta 3
- Molecular classification
- Cytokine, Growth Factor, TGF-beta Superfamily
01
Overview
Transforming growth factor beta-3 (TGF-β3) is a cytokine that belongs to the TGF-β superfamily. It regulates cell growth, differentiation, embryogenesis, tissue development, and plays a critical role in palate formation and wound healing. It signals through TGF-beta receptor II and SMAD pathways. Dysregulation is linked to developmental disorders and fibrosis.
- Other names
- TGFB3
02
Mechanism of action
Binds to TGF-beta receptor II, activating SMAD-dependent signaling pathways to regulate gene expression involved in cell growth, differentiation, and ECM production.
03
Biological functions
Cell growth regulationCell differentiationCell motilityApoptosisExtracellular matrix regulationWound healingEmbryogenesisTumor suppression
04
Disease associations
Cleft palateFibrosisMyocardial infarctionLiver diseaseCancer
05
Safety considerations
Dysregulation can contribute to developmental disorders and pathological fibrosisAvotermin (recombinant human TGF-beta 3) failed Phase III clinical trials for scar reduction
06
Interacting drugs
Avotermin
07
Biomarkers
Elevated serum levels predict risk for NAFLD
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