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Target intelligence / Profile preview
Transforming Growth Factor-beta Activated Kinase 1 (TAK1)
- Target
- TAK1
- Molecular classification
- Serine/threonine kinase, MAPKKK, Enzyme
01
Overview
TAK1/MAP3K7 is an essential signal transducer integrating pro-inflammatory cues into cellular outcomes that govern immunity, development, tissue remodeling—and when dysregulated—disease pathogenesis across multiple organ systems. It is activated by various stimuli including TGF-beta, IL-1, TNF-alpha and TLRs and regulates downstream signaling pathways such as NF-kappaB and JNK/p38 MAPK.
- Other names
- MAP3K7Mitogen-Activated Protein Kinase Kinase Kinase 7
02
Mechanism of action
Inhibition of TAK1 kinase activity
03
Biological functions
Cell death regulationCell survival regulationInflammation controlImmune response controlSignal transductionGene transcriptionStress response
04
Disease associations
Immune deficienciesInflammationCancerFibrosisCardiovascular remodeling
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