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Transforming Growth Factor Beta Pathway (None)

Target: None
Molecular classification: Signaling pathway

Overview

The transforming growth factor beta (TGF-β) pathway is a highly conserved signaling cascade that regulates a wide array of cellular processes in both embryonic development and adult tissue homeostasis. These processes include cell growth, differentiation, migration, apoptosis, immune regulation, and maintenance of cellular homeostasis. The pathway is also crucial for the regulation of inflammation (notably in the gut), stem cell differentiation, and T-cell function. Dysregulation is implicated in numerous diseases, including cancer progression/suppression, fibrosis, immune disorders and developmental abnormalities.

Biological functions

Signal transductionCell growthCell differentiationCell migrationApoptosisImmune regulationCellular homeostasisInflammation regulationStem cell differentiationT-cell function

Disease associations

Cancer progression/suppressionFibrosisImmune disordersDevelopmental abnormalities

Safety considerations

Context-dependent effects in tumorigenesis

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