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Target intelligence / Profile preview
Transforming Growth Factor Beta Receptor 3 (TGFBR3)
- Target
- TGFBR3
- Molecular classification
- Receptor, Cell surface proteoglycan, Co-receptor
01
Overview
TGFBR3, also known as betaglycan, is a cell-surface proteoglycan that functions as a co-receptor for TGF-beta ligands. It enhances ligand binding to signaling receptors and modulates both Smad-dependent and non-Smad signaling pathways. It plays critical roles in embryonic development, immune regulation, and tissue homeostasis. Loss or dysfunction of TGFBR3 is implicated in cancer progression and metastasis.
- Other names
- Type III TGF-beta receptorBetaglycan
02
Mechanism of action
Modulates TGF-beta ligand presentation to signaling receptors; Acts as a ligand trap when cleaved; Modulates Smad and non-Smad signaling pathways
03
Biological functions
Ligand bindingSignal transductionDevelopmental regulationImmune system regulationTumor suppressionModulation of TGF-beta signalingCellular homeostasisRegulation of cell migrationRegulation of cell invasionAngiogenesis regulationCell proliferation regulation
04
Disease associations
CancerAutoimmunityInflammationDevelopmental disorders
05
Safety considerations
Disruption can lead to severe developmental abnormalitiesLoss of expression can promote cancer progression and metastasis
06
Biomarkers
Expression levels as a prognostic marker in cancer metastasis
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