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Target intelligence / Profile preview
Transforming growth factor beta receptor type 2 (TGFBR2)
- Target
- TGFBR2
- Molecular classification
- Receptor, Transmembrane serine/threonine protein kinase
01
Overview
Transforming growth factor beta receptor type 2 (TGFBR2) is a critical cell surface receptor involved in the TGF-β signaling pathway, which regulates numerous cellular processes including proliferation, differentiation, apoptosis, and extracellular matrix production. It acts as a tumor suppressor gene by helping prevent uncontrolled cell proliferation. Mutations in the *TGFBR2* gene are linked to several human diseases.
- Other names
- TGF-beta receptor type II
02
Mechanism of action
TGFBR2 binds TGF-β ligands, forming a heteromeric complex with TGFBR1. TGFBR2 phosphorylates and activates TGFBR1, which then phosphorylates downstream effectors such as SMAD proteins. These complexes translocate into the nucleus to regulate transcription of target genes.
03
Biological functions
Cell proliferationDifferentiationApoptosisMotility/migrationSignal transductionCell cycle arrestWound healingImmunosuppressionTumorigenesis
04
Disease associations
CancerMarfan syndrome-like conditionsLoeys-Dietz syndrome type IIFamilial thoracic aortic aneurysm/dissection (TAAD)
05
Safety considerations
Mutations can lead to loss of tumor suppressor function.
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