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Target intelligence / Profile preview
Transforming Growth Factor Beta Receptor Type 3 (TGFBR3)
- Target
- TGFBR3
- Molecular classification
- Receptor, Cell-surface proteoglycan, Coreceptor
01
Overview
Transforming growth factor beta receptor type 3 (TGFBR3), also known as betaglycan, is a cell-surface proteoglycan that acts as a coreceptor for the transforming growth factor beta (TGF-β) superfamily of ligands. It is the most widely expressed TGF-β receptor and plays a crucial role in mediating ligand binding to other TGF-β receptors, particularly TGFBR2. Unlike type I and II receptors, TGFBR3 does not possess intrinsic kinase activity and is generally considered a non-signaling or accessory/coreceptor within the canonical pathway. Its main function is to present or concentrate these ligands at the cell surface for efficient transfer to signaling receptors such as TGF-beta receptor II (TGFBR2).
- Other names
- BetaglycanTGBRIIITGFRIIIBGCAN
02
Mechanism of action
Facilitates ligand presentation to TGFBR2
03
Biological functions
Ligand presentationLigand transferReservoir for TGF-beta superfamily membersRegulation of cell proliferationRegulation of differentiationRegulation of migrationRegulation of apoptosisEmbryonic developmentTissue homeostasisWound healingImmune regulationVascular formationBone growth regulation
04
Disease associations
Developmental disordersLoeys-Dietz syndrome VCancerCardiovascular defects
05
Safety considerations
Dysregulation can lead to developmental syndromesDysregulation can lead to cardiovascular defects
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