Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transforming Growth Factor Beta Receptor Type I (TGFBR1)
- Target
- TGFBR1
- Molecular classification
- Receptor, Transmembrane serine/threonine kinase
01
Overview
TGFBR1 is a transmembrane serine/threonine kinase receptor that plays a central role in the transforming growth factor-beta (TGF-β) signaling pathway. Upon ligand binding and activation by TGFBR2, TGFBR1 phosphorylates SMAD proteins, propagating signals into the cell to regulate cellular processes like proliferation, differentiation, and apoptosis. It has dual roles as tumor suppressor/promoter, and is implicated in various diseases, including Loeys-Dietz syndrome and cancer. Several small-molecule inhibitors target TGFBR1 kinase activity.
- Other names
- ALK5Activin A receptor type II-like kinase
02
Mechanism of action
Small-molecule inhibitors that target TGFBR1's kinase activity, preventing phosphorylation and activation of downstream signaling molecules such as SMADs.
03
Biological functions
Signal transductionCell proliferationDifferentiationApoptosisMotilityImmune homeostasisStem-cell self-renewalCell cycle arrest
04
Disease associations
Loeys-Dietz Syndrome Type IAortic Aneurysm SyndromeMultiple Self-Healing Squamous EpitheliomaCancerFibrotic diseases
05
Safety considerations
Context-dependent tumor suppressor/promoter roles requiring careful consideration in cancer therapy.Potential for off-target effects due to broad expression across various tissues.
06
Interacting drugs
GW788388
5 more in the full profile.
Beyond the preview
Go deeper on Transforming Growth Factor Beta Receptor Type I (TGFBR1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transforming Growth Factor Beta Receptor Type I (TGFBR1).