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Target intelligence / Profile preview
Transforming Growth Factor Beta Type II Receptor (TGFBR2)
- Target
- TGFBR2
- Molecular classification
- Receptor, Serine/threonine kinase, Transmembrane protein
01
Overview
Transforming growth factor beta type II receptor (TGFBR2) is a transmembrane serine/threonine protein kinase that plays a central role in the TGF-β signaling pathway. It acts as a receptor for TGFB1, TGFB2, and TGFB3, regulating diverse cellular processes. Mutations or dysregulation are implicated in several diseases, including Loeys-Dietz syndrome, Marfan syndrome, Osler–Weber–Rendu syndrome, and various cancers.
02
Mechanism of action
Ligand binding induces phosphorylation and activation of TGFBR1, which then propagates intracellular signaling cascades through Smad proteins or non-Smad pathways such as MAP kinases or PI3K/Akt pathways.
03
Biological functions
Cell proliferationDifferentiationApoptosisMotilityImmune regulationExtracellular matrix productionWound healingSignal transduction
04
Disease associations
CancerLoeys-Dietz syndromeMarfan syndromeOsler–Weber–Rendu syndromeConnective tissue disorders
05
Safety considerations
Potential for off-target effects due to involvement in multiple signaling pathways.
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