Transgelin–actin complex

The **transgelin–actin complex** refers to the physical and functional interaction between *transgelin* (a calponin family actin-binding protein, also known as SM22α or encoded by the TAGLN gene[7][9][5]) and actin filaments within cells. Transgelins have three isoforms (transgelin-1/TAGLN/SM22α, transgelin-2/TAGLN2, transgelin-3/TAGLN3), and function as actin cross-linking or gelling proteins, stabilizing the actin cytoskeleton and affecting cell contractility, shape, and motility[7][2][3][4]. These proteins are abundant in smooth muscle and fibroblasts and participate in actin bundling, cross-linking, and inhibition of branched actin nucleation by interfering with Arp2/3 complex–mediated actin dynamics[4]. Changes in transgelin–actin interactions are implicated in cancer progression, cell migration, and differentiation[5][6]. The *complex* itself is a biochemical entity formed in vivo and in vitro, but it is not typically considered a distinct therapeutic target; rather, transgelin (especially transgelin-2) is the druggable component, particularly in oncology and regenerative contexts[2][5][6]. **Note:** The term “transgelin–actin complex” is not a canonical name for a single molecule or receptor, but designates a protein-protein interaction or functional state. If you are seeking information about the druggable protein, use “Transgelin” (for general) or “Transgelin-1” / “Transgelin-2” when isoform specificity is required[3][5]. **Summary of why this is considered incorrect:** - “Transgelin–actin complex” is a *protein-protein interaction*, not a canonical drug target entity (like a receptor, enzyme, or transporter)[2][4][5][6]. - The correct molecular target is *Transgelin* (and its isoforms), not the “complex”[2][3][6]. - No generally accepted canonical abbreviation, gene symbol, or drug classification exists for a transgelin–actin *complex*. - Most drug development and biomarker literature focus on the protein transgelin (e.g., TAGLN, SM22α), not its complex with actin[2][5][6].

Other names

Transgelin–actin bindingTAGLN–actin complexSM22–actin complex

Inhibition of actin-binding or actin-bundling; Modulation of actin polymerization dynamics