Transgene delivered by retroviral vector

A transgene delivered by retroviral vector is a therapeutic or experimental gene incorporated into a retroviral DNA backbone and introduced into a target cell population via retroviral transduction. This process uses a modified (typically replication-defective) retrovirus to integrate the transgene into the host cell genome, ensuring stable inheritance of the gene during cell division. Retroviral vectors are widely used in gene therapy—especially for ex vivo modification of dividing cells (e.g., T cells, stem cells)—because the integration enables persistent expression of the delivered gene. The choice of retroviral vector, and safeguards such as self-inactivating elements, aim to maximize efficacy and minimize risks such as insertional mutagenesis or immune rejection.

Other names

Retroviral vector-delivered transgeneVector-mediated gene deliveryRetrovirus-transduced gene

Gene addition (delivers functional genetic material to cells via integration, enabling expression of a recombinant protein or RNA)