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Transglutaminase 2 (TG2)
- Target
- TG2
- Molecular classification
- Enzyme, Transglutaminase, G-protein
01
Overview
Transglutaminase 2 (TG2) is a multifunctional enzyme that catalyzes protein crosslinking, deamidation, and acts as a GTPase. It participates in various cellular processes including cell growth, differentiation, apoptosis, inflammation, and tissue repair. Dysregulation of TG2 is implicated in diseases such as fibrosis, cancer, neurodegenerative diseases, cardiovascular disease and celiac disease.
- Other names
- Tissue TransglutaminasetTGProtein-glutamine γ-glutamyltransferase
02
Mechanism of action
TG2 inhibitors block transamidation activity, GTP binding, and/or protein interactions.
03
Biological functions
Transamidation/crosslinkingDeamidationGTPase/G-protein functionProtein disulfide isomerizationKinase activityCell growthDifferentiationApoptosis/cell deathInflammationTissue repair/wound healingScaffolding
04
Disease associations
FibrosisCancerNeurodegenerative DiseasesCardiovascular DiseaseCeliac Disease
05
Safety considerations
Potential for off-target effects due to ubiquitous expression and multiple functions.Inhibition may have context-dependent effects (protective vs. pathological).
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