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Target intelligence / Profile preview
Transient Receptor Potential Ankyrin 1 Channel (TRPA1)
- Target
- TRPA1
- Molecular classification
- Ion channel, TRP channel, Ankyrin subfamily
01
Overview
TRPA1 is a non-selective, Ca(2+)-permeable cation channel that functions as a sensor for pain, cold, itch, and chemical irritants. It plays significant roles in nociception, inflammation, and cellular responses to environmental stressors. TRPA1 is an important target for neuropathic pain, inflammatory pain, migraine pain, cough sensitivity, and airway inflammation/fibrosis.
- Other names
- ANKTM1
02
Mechanism of action
Activation by electrophilic irritants, noxious cold temperatures, and inflammatory mediators; modulation of inflammatory signaling pathways (TLR4/NF-κB); regulation of calcium influx.
03
Biological functions
NociceptionPain sensationCold sensingItch sensingInflammationSensory perceptionChemosensor
04
Disease associations
Neuropathic painInflammatory painMigraine painCough sensitivityAirway inflammationAirway fibrosis
05
Interacting drugs
Mustard oil (allyl isothiocyanate)
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