Transient receptor potential canonical 1-containing store-operated calcium channel (TRPC1-SOC)

TRPC1-containing store-operated calcium channels (SOCs) are heteromeric protein complexes that play a pivotal role in store-operated calcium entry (SOCE), a fundamental mechanism for regulating intracellular calcium levels. These channels are primarily composed of the Transient Receptor Potential Canonical 1 (TRPC1) protein, which functions in coordination with the endoplasmic reticulum (ER) calcium sensor STIM1 and the pore-forming protein Orai1. Upon the depletion of ER calcium stores, STIM1 undergoes a conformational change and translocates to ER-plasma membrane junctions, where it recruits and activates TRPC1 and Orai1 to facilitate calcium influx. This influx is essential for refilling internal stores and activating downstream signaling pathways involved in cell growth, motility, and survival. Dysregulation of TRPC1-containing SOCs is strongly linked to various diseases, including several types of cancer where they promote metastasis and chemoresistance, as well as cardiovascular conditions like cardiac hypertrophy and pulmonary hypertension. While these channels represent promising therapeutic targets, the development of effective drugs is hindered by the lack of highly selective inhibitors and the widespread physiological distribution of the channel components.

Other names

TRPC1-containing SOCTRPC1-Orai1-STIM1 complexTRPC1-mediated store-operated calcium channelCapacitative calcium entry channel

Inhibition of store-operated calcium entry (SOCE) by blocking the channel pore or disrupting the interaction between TRPC1 and its regulatory proteins STIM1 and Orai1.